Houston Street runs east-west. Walk in the westward direction, along the north side of Houston street. You will cross Broadway (very busy), then Mercer Street (quiet), and about 100 feet later, find a foot path on your right. Follow that foot path, and take the first left on that foot path into a large open plaza area (with a green grounds in the center). One of the 3 tall apartment building around that plaza is 100 Bleecker Street, where we live.
A cab takes at least 40-60 minutes. The A train alternative takes a little over one hour (but on weekends and late hours can be slower). The Carey bus + subway is also roughly one hour.