References:
Expression Profiling using cDNA arrays: Duggan et al, Nature Genetics
1999.
Cluster Analysis and Display of genome wide expression patterns: Eisen
et al, PNAS, 1998
Genomics syllabus: G23.1128
Organizer/Instructor of Record: Benfey
Classroom: 206 Main
Format: 14 x 3 hour classes: 2 hour lecture; 1 hour discussion.
Evaluation: 3 quizzes (20% each), paper (20%) and class participation (20%).
Textbooks
Required: "Genomes" T.A. Brown; Wiley-Liss publisher.
Recommended: "Gene Discovery Lab" Benfey; Brooks/Cole
Time: Thursdays 3:30-6:30
Schedule/Instructor:
Sept. 6
Introduction, background, history - Benfey
[Brown pp. 2-12]
Sept. 13
Functional genomics: expression analysis - Benfey, Coruzzi and Mishra (Courant)
[Brown pp. 107-110; 188-201]
Sept. 20
Genomics and human origins - Disotell (Anthropology)
[Brown pp. 406-412]
Sept. 27
Structural genomics: sequencing and mapping - McCombie (CSHL)
[Brown pp. 38-83, 135-142]
Oct. 4
Human Genome Project and human diversity - Desnick (MSSM)
[Brown pp. 15-35; 406-413]
Oct. 11 Discussion + Quiz
Oct. 18
Genomics and human disease: gene discovery for Mendelien traits - Desnick (MSSM)
[Brown pp. 330-365]
Oct. 25
Genomic approaches to complex disease traits- Bruce Gelb (MSSM)
[Barnum pp. 179-188]
Nov. 1
Comparative genomics - Benfey and Shasha (Courant)
[Brown pp. 103-109; 368-389]
Nov. 8 Discussion + Quiz
Nov. 15
High throughput Genetics/ Genomics and Agriculture - Martienssen (CSHL)
[Brown pp. 329-346]
Nov. 29
Phylogenomics - DeSalle (AMNH)
[Brown pp. 282-295; 392-406]
Dec. 6
(Wednesday) Proteomics - Neubert (NYU med)
[Brown 231-262]
Dec. 12 Discussion + Quiz
Dec. 12 Papers due