Genomics syllabus G23.1128 Organizer/Instructor of Record: Benfey Classroom: Main 520 (5th floor Main Building - entrance on Washington Place) Format: 14 x 3 hour classes: 2 hour lecture; 1 hour discussion of current literature. Evaluation: Exam (40%), paper (40% ) and class participation (20%). Target audience: First year graduate and upper level undergraduates (1000 level). Textbooks Required: "Genomes" T.A. Brown; Wiley-Liss publisher. Recommended:" Biotechnology, an introduction" S. Barnum: Wadsworth Time: Thursdays 3:30-6:30 Schedule/Instructor: Sept. 7 Introduction/overview - Benfey [Brown pp. 2-12] Sept. 14 Functional genomics: expression analysis - Benfey and Coruzzi and Mishra (Courant) [Brown pp. 107-110; 188-201; ] Sept. 21 High-through-put genetics and gene-trap analysis - Martienssen (CSHL) [Brown pp. 96-103] Sept. 28 Structural genomics: sequencing and mapping - McCombie (CSHL) [Brown pp. 38-83, 135-142] Oct. 5 Bioinformatics of sequencing and mapping - Mishra (Courant) [Brown pp. 14-35; 86-96] Oct. 12 Human Genome Project and human diversity - Desnick (MSSM) [Brown pp. 15-35; 406-413] Oct. 19 Phamacogenomics: genomics and drug discovery - Bailey (Merck) [Brown pp. 264-277] [Barnum pp. 169-177] Oct. 26 Genomics and human disease: gene discovery for Mendelien traits - Desnick (MSSM) [Brown pp. 330-365] Nov. 2 Evolution and genomics: comparative genomics - Benfey and Shasha (Courant) [Brown pp. 103-109; 368-389] Nov. 9 Genomic approaches to complex disease traits- Bruce Gelb (MSSM) [Barnum pp. 179-188] Nov. 16 EXAM Nov. 30 Genomics and agriculture - Last (Cereon) [Barnum pp. 91-104] Dec. 7 Phylogenomics - DeSalle (AMNH) and Coruzzi [Brown pp. 282-295; 392-406] Dec. 13 (Wednesday) Genomics and human origins - Disotell (Anthropology) [Brown pp. 406-412] Dec. 15 Papers due