Nov 8: Mishra's Lecture on Microarrays

References:

Expression Profiling using cDNA arrays: Duggan et al, Nature Genetics 1999.
Cluster Analysis and Display of genome wide expression patterns: Eisen et al, PNAS, 1998



  Genomics syllabus: G23.1128


  Organizer/Instructor of Record: Benfey

  Classroom: 206 Main

  Format:  14 x 3 hour classes: 2 hour lecture; 1 hour discussion.

  Evaluation: 3 quizzes (20% each), paper (20%) and class participation (20%).

  Textbooks
  Required: "Genomes"  T.A. Brown; Wiley-Liss publisher.
  Recommended: "Gene Discovery Lab" Benfey; Brooks/Cole

  Time: Thursdays 3:30-6:30

  Schedule/Instructor:

  Sept. 6
  Introduction, background, history - Benfey
  [Brown pp. 2-12]

  Sept. 13
  Functional genomics: expression analysis - Benfey, Coruzzi and Mishra (Courant)
  [Brown pp. 107-110; 188-201]

  Sept. 20
  Genomics and human origins - Disotell (Anthropology)
  [Brown pp. 406-412]

  Sept. 27
  Structural genomics: sequencing and mapping  - McCombie (CSHL)
  [Brown pp. 38-83, 135-142]

  Oct. 4
  Human Genome Project and human diversity - Desnick (MSSM)
  [Brown pp. 15-35; 406-413]

  Oct.  11 Discussion + Quiz   

  Oct. 18
  Genomics and human disease: gene discovery for Mendelien traits - Desnick (MSSM)
  [Brown pp. 330-365]

  Oct. 25
  Genomic approaches to complex disease traits- Bruce Gelb (MSSM)
  [Barnum pp. 179-188]

  Nov. 1
  Comparative genomics - Benfey and Shasha (Courant)
  [Brown pp. 103-109; 368-389]

  Nov. 8 Discussion + Quiz

  Nov.  15
  High throughput Genetics/ Genomics and Agriculture - Martienssen (CSHL)
  [Brown pp. 329-346]

  Nov.  29
  Phylogenomics - DeSalle (AMNH)
  [Brown pp. 282-295; 392-406]

  Dec. 6
  (Wednesday) Proteomics - Neubert (NYU med)
  [Brown 231-262]

  Dec. 12 Discussion + Quiz

  Dec. 12  Papers due