Genomics:

Genomics syllabus 
 
G23.1128

Organizer/Instructor of Record: Benfey

Classroom: Main 520 (5th floor Main Building - entrance on Washington
Place)

Format:  14 x 3 hour classes: 2 hour lecture; 1 hour discussion of
current literature.

Evaluation: Exam (40%), paper (40% ) and class participation (20%).

Target audience: First year graduate and upper level undergraduates
(1000 level).

Textbooks
Required: "Genomes"  T.A. Brown; Wiley-Liss publisher.
Recommended:" Biotechnology, an introduction" S. Barnum: Wadsworth

Time: Thursdays 3:30-6:30

Schedule/Instructor:

Sept. 7 Introduction/overview - Benfey
     [Brown pp. 2-12]

Sept. 14 Functional genomics: expression analysis - Benfey and Coruzzi
and Mishra (Courant)
     [Brown pp. 107-110; 188-201; ]

Sept. 21 High-through-put genetics and gene-trap analysis -
Martienssen (CSHL)
    [Brown pp. 96-103]

Sept. 28 Structural genomics: sequencing and mapping  - McCombie
(CSHL)
       [Brown pp. 38-83, 135-142]

Oct. 5 Bioinformatics of sequencing and mapping - Mishra (Courant)
    [Brown pp. 14-35; 86-96]
        
Oct.  12 Human Genome Project and human diversity - Desnick (MSSM)
      [Brown pp. 15-35; 406-413]      

Oct. 19 Phamacogenomics: genomics and drug discovery - Bailey (Merck)
   [Brown pp. 264-277] [Barnum pp. 169-177]

Oct. 26 Genomics and human disease: gene discovery for Mendelien
traits - Desnick (MSSM)
        [Brown pp. 330-365]

Nov. 2 Evolution and genomics: comparative genomics - Benfey and
Shasha (Courant)
    [Brown pp. 103-109; 368-389]

Nov. 9 Genomic approaches to complex disease traits- Bruce Gelb (MSSM)
      [Barnum pp. 179-188]

Nov.  16 EXAM

Nov.  30 Genomics and agriculture  - Last (Cereon)
     [Barnum pp. 91-104]

Dec. 7  Phylogenomics - DeSalle (AMNH) and Coruzzi 
  [Brown pp. 282-295; 392-406]

Dec. 13 (Wednesday)  Genomics and human origins - Disotell
(Anthropology)
   [Brown pp. 406-412]

Dec. 15  Papers due